张宏娜，yl8cc永利特聘教授，副教授，硕士生导师，山东省泰山学者青年专家，山东省海外优青。2017年毕业于中国科学院生态环境研究中心，获得博士学位。2017–2021年于香港浸会大学环境与生物分析国家重点实验室从事博士后研究工作，科研领域为污染物暴露相关的环境健康研究。主持国家自然科学基金项目2项，省级项目2项，发表学术论文30余篇，其中第一/通讯作者（含并列）论文17篇，包括Nature Communications, Environmental Science & Technology, Journal of Hazardous Materials, Environmental Pollution等领域知名期刊论文，授权国家发明专利四项。
一、主要研究方向
1、污染物的环境行为、生物效应及健康风险；
2、多组学技术在环境健康研究中的应用；
3、基于质谱的生物标志物检测技术和方法。
二、代表性科研成果
1）学术论文
[1] Hongna Zhang#, Katherine Z. Sanidad#, Jianan Zhang, Guangqiang Wang, Rong Zhang, Chengchen Hu, Yongfeng Lin, Thomas D. Haggerty, Julie Parsonnet, Yuxin Zheng, Guodong Zhang*, Zongwei Cai*. Microbiota-mediated reactivation of triclosan oxidative metabolites in colon tissues. Journal of Hazardous Materials, 2023, 445, 130509. (#Co-first author)
[2] Jianan Zhang#, Morgan E. Walker#, Katherine Z. Sanidad#, Hongna Zhang#, Yanshan Liang, Ermin Zhao, Katherine Chacon-Vargas, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Guangqiang Wang, Joshua B. Simpson, Parth B. Jariwala, Violet V. Beaty, Jun Yang, Haixia Yang, Anand Panigrahy, Lisa M. Minter, Daeyoung Kim, John G. Gibbons, LinShu Liu, Zhengze Li, Hang Xiao, Valentina Borlandelli, Hermen S. Overkleeft, Erica W. Cloer, Michael B. Major, Dennis Goldfarb, Zongwei Cai*, Matthew R. Redinbo*, Guodong Zhang*. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nature Communications, 2022, 13(1), 136. (#Co-first author)
[3] Hongna Zhang, Yanshan Liang, Pengfei Wu, Xianru Shi, Guodong Zhang, Zongwei Cai*. Continuous dermal exposure to triclocarban perturbs the homeostasis of liver-gut axis in mice: Insights from metabolic interactions and microbiome shifts. Environmental Science & Technology, 2021, 55(8), 5117–5127.
[4] Hongna Zhang, Katherine Z. Sanidad, Lin Zhu, Julie Parsonnet, Thomas D. Haggerty, Guodong Zhang*, Zongwei Cai*. Frequent occurrence of triclosan hydroxylation in mammals: A combined theoretical and experimental investigation, Journal of Hazardous Materials, 2021, 407, 124803.
[5] Guangqiang Wang#, Hongna Zhang#, Jianan Zhang#, Katherine Z. Sanidad, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Haixia Yang, Lianzhong Ai, Minhao Xie, Zongwei Cai*, Guodong Zhang*. Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved. Science of The Total Environment, 2021, 787, 147677. (#Co-first author)
[6] Yanshan Liang, Hongna Zhang*, Zongwei Cai*. New insights into the cellular mechanism of triclosan-induced dermal toxicity from a combined metabolomic and lipidomic approach. Science of The Total Environment, 2021, 757, 143976. (*Co-corresponding author)
[7] Qiong Luo, Hongna Zhang*, Yanqiu Zhou, Zehua Liu, Zongwei Cai*. Simultaneous determination of triclosan, triclocarban, triclocarban metabolites and byproducts in urine and serum by ultra-high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2021, 35, e9117. (*Co-corresponding author)
[8] Hongna Zhang, Yao Lu, Yanshan Liang, Lilong Jiang, Zongwei Cai*. Triclocarban-induced responses of endogenous and xenobiotic metabolism in human hepatic cells: Toxicity assessment based on nontargeted metabolomics approach. Journal of Hazardous Materials, 2020, 392, 122475.
[9] Hongna Zhang, Bei Wen*, Honglin Huang, Sen Wang, Zongwei Cai, Shuzhen Zhang. Biotransformation of 6:2 fluorotelomer alcohol by the whole soybean (Glycine max L. Merrill) seedlings. Environmental Pollution, 2020, 257, 113513.
[10] Minhao Xie#, Hongna Zhang#, Weicang Wang, Heather L. Sherman, Lisa M. Minter, Zongwei Cai, Guodong Zhang*. Triclocarban exposure exaggerates spontaneous colonic inflammation in Il-10-/- mice. Toxicological Sciences, 2020, 174(1), 92–99. (#Co-first author)
[11] Hongna Zhang, Xiaojian Shao, Hongzhi Zhao, Xiaona Li, Juntong Wei, Chunxue Yang, Zongwei Cai*. Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes. Environmental Science & Technology, 2019, 53(9), 5406–5415.
[12] Hongna Zhang, Bei Wen*, Wen Wen, Yibing Ma, Xiaoyu Hu, Yali Wu, Lei Luo, Shuzhen Zhang. Determination of perfluoroalkyl acid isomers in biosolids, biosolids-amended soils and plants using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography B, 2018, 1072, 25–33.
[13] Hongna Zhang, Bei Wen*, Xiaoyu Hu, Yali Wu, Ying Pan, Honglin Huang, Liu Liu, Shuzhen Zhang. Uptake, translocation and metabolism of 8:2 fluorotelomer alcohol in soybean (Glycine max L. Merrill). Environmental Science & Technology, 2016, 50(24), 13309–13317.
[14] Hongna Zhang, Bei Wen*, Xiaoyu Hu, Yali Wu, Lei Luo, Zien Chen, Shuzhen Zhang. Determination of fluorotelomer alcohols and their degradation products in biosolids-amended soils and plants using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A, 2015, 1404, 72–80.
[15] 张宏娜, 温蓓*, 张淑贞. 全氟烷基羧酸前体物氟调醇的污染水平与生物转化研究进展, 环境化学, 2021, 40(1), 65–82.
[16] 张宏娜, 温蓓*, 张淑贞. 全氟和多氟烷基化合物异构体的分析方法、环境行为和生物效应研究进展, 环境化学, 2019, 38(1), 42–50.
[17] 张宏娜, 温蓓*, 马义兵, 胡晓宇, 张淑贞. 大田条件下污泥施用土壤中全氟烷酸化合物的玉米吸收和传输, 环境化学, 2018, 37(9), 1885–1894.（封面文章）
2）发明专利
[1] 蔡宗苇, 张宏娜. 一种羟基化三氯卡班的制备方法与应用. ZL201810785477.3
[2] 蔡宗苇, 张宏娜, 宋媛媛. 一种三氯生磺酸铵及其制备方法与应用. ZL201810791720.2
[3] 温蓓, 张宏娜, 张淑贞. 土壤和/或植物中全氟化合物同分异构体的测定方法. ZL201610346303.8
[4] 温蓓, 张宏娜, 张淑贞. 土壤和植物中氟调聚醇（FTOHs）羧酸类降解产物的测定方法. ZL201410352995.8
三、主要科研项目
[1] 国家自然科学基金面上项目，柴油机尾气经AHR介导致肝脏脂质沉积的机制及代谢标志物研究，2023/01-2026/12，主持 。
[2] 国家自然科学基金“双碳计划与人群健康”专项项目，新能源产业重要职业性有害因素的健康效应与毒性机制研究，2023/01-2026/12，参与。
[3] 山东省优秀青年科学基金项目（海外），环境污染与健康，主持。
[4] 国家自然科学基金青年科学基金项目，基于质谱代谢组学的三氯卡班及其羟基代谢物的肝脏毒性机制研究，2019/01–2021/12，主持。
[5] 环境化学与生态毒理学国家重点实验室开放基金，三氯卡班慢性皮肤暴露的脑神经影响及机制，2021/12–2023/11，主持。
四、主要学术兼职
中华预防医学会环境卫生分会委员
《Environmental Geochemistry and Health》副主编
《精准医学杂志》青年编委
五、主要科研技术奖励
2020年度中国分析测试协会科学技术奖（CAIA奖）特等奖（排名9/10）：环境毒理研究的质谱新方法
五、联系方式
E-mail：hnzhang@qdu.edu.cn
